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The metabolic interplay between the vascular and skeletal systems thus emerges as a therapeutic focal point, in which CIT enhances endothelial responsiveness, leucine promotes muscle anabolic processes, and exercise serves to integrate both systems through hemodynamic and molecular stimuli

Additionally, rich in flavonoids-including apiin, apigenin, crisoeriol, and luteolin as well as carotenoids lutein, and zeaxanthin that have strong antioxidant and kidney supportive properties

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Their heart failure symptoms and physical limitations are due to impaired filling and relaxation of the left ventricle

Aging-related enzyme decline : GR activity tends to decrease with age in many tissues, contributing to the age-associated increase in oxidative damage